Intelligence for the science of life.
It searches the literature, analyzes and computes your data, supports research, and optimizes CMC process development — from the first question to the final process. 68 expert skills, 35 life-science data sources, in-region compute.
CMC knowledge is tribal — and that's the problem.
Every process scientist carries 10 years of habits, preferences, unwritten rules.
When they leave, that knowledge leaves with them. When a new molecule arrives, half the team relearns it.
What if the knowledge stayed?
One name. Four domains.
Thoth was the Egyptian god of knowledge, writing, science, and reckoning. His four domains map, almost one to one, onto what every scientist still does each day — the brand is the product spec.
Six capability domains, from the first question to the final process.
From target assessment and structure design through the process tree and DoE to the final IND/NDA draft.
Target assessment · deep research · indication dossiers
Assess a target against the evidence, run multi-step literature research, and compile an indication dossier — grounded in 35 connected life-science sources (UniProt, ChEMBL, Open Targets, PubMed, ClinicalTrials.gov, openFDA, and domestic sources including iProX and CNCB).
Folding · binder and antibody design · docking · binding free energy
Protein folding and co-folding, de novo binder scaffolds, inverse-folding sequence design, molecular docking, and binding free energy — routed to in-region GPU or compliant domestic providers. Every run captures provenance (seed, params, input hash); structures render as interactive 3D.
ASO / siRNA design · mRNA · LNP formulation
Modality-aware oligonucleotide design: thermodynamics, off-target screening, and real secondary-structure accessibility (ViennaRNA MFE). Chemistry modification advice is evidence-table driven — no evidence, no recommendation. Controlled-sequence screening is a hard gate.
Process development assistant
User describes the molecule + target; the Agent recommends a process across capture / polish / viral / final steps — with resin, buffer, parameter ranges, risk flags, and alternatives per step. Backed by a real chromatography-column catalog and multi-tenant process records.
DoE design · execution · analysis
Live DoE workspace backed by a Gaussian-process + active-learning microservice: factors / responses, response surface, and a recommended next run. Writes to an auditable process record.
Impurity attribution + method development
Upload HPLC / MS data; the Agent attributes impurity sources and recommends characterization methods + limits.
Risk assessment + ICH Q9 automation
FMEA / Risk Assessment templates + AI fill, outputs IND/NDA report drafts.
CMC document drafting
Development report · Process description · Specification draft generation, FDA / NMPA style-matched.
Competitive & pipeline intelligence · scheduled digests
Track a related company’s development pipeline and summarize updates as they land; compile a weekly industry-trend digest. One of the scheduled-task types — runs in the background and delivers to you on cadence.
GxP-ready from day one.
We didn't add compliance as an afterthought. It's a primary engineering constraint.
Three roles. Three force multipliers.
“Turns the P-2 → P-3 transition from trial-and-error into a few evidence-backed DoE rounds.”
“InThoth drafts the dev report; I spend my time on the decisions and the review.”
“A small team punches above its weight — InThoth keeps accumulated process know-how at hand.”
An InThoth process design.
Common questions
InThoth Enterprise — your lab, self-driving.
Standard InThoth is the agent beside each scientist. Enterprise is the intelligence layer across the whole operation. It rides on the LIMS, MES, ELN, SCADA and QMS you already run — and on the instruments we build. We integrate; we don't rip and replace.
- Digital-twin lab — a living virtual replica of your process and instruments, fed by real data; simulate and optimize a run before you spend a batch
- Self-driving lab (in development) — design a campaign, run it on instruments, read results, decide what is next, unattended and around the clock
- InMail (available now) — triage, draft, and extract action items, tied back to your process knowledge base
- Enterprise integration (bespoke) — plug into your LIMS / MES / ELN / SCADA / QMS / ERP and become the intelligence and orchestration layer across them
Compliance and deployment: 21 CFR Part 11 · GMP · full audit trail · data integrity (ALCOA+); on-prem, private / VPC, and air-gapped options. Your process data never has to leave your control.
Stop relearning what you already know.
Start free — upgrade to Plus / Pro / Max any time.